Transient up-regulation of retinal EphA3 and EphA5, but not ephrin-A2, coincides with re-establishment of a topographic map during optic nerve regeneration in goldfish

Exp Neurol. 2003 Oct;183(2):593-9. doi: 10.1016/s0014-4886(03)00211-5.

Abstract

Eph tyrosine kinase receptors and their ligands, the ephrins, play a key role in the establishment of retinotectal topography during development. Tectal up-regulation of ephrin-A2 in goldfish, coincident with the reestablishment of a retinotectal map, suggests a similar role during optic nerve regeneration. Here we report a complementary study of EphA3, EphA5 and ephrin-A2 expression in the retina. EphA3 and EphA5 are transiently up-regulated as ascending naso-temporal gradients, whereas ephrin-A2 remains uniform. The expression profiles differ from those in developing chick and mouse, suggesting that different combinations of retinal Eph receptors and ligands can generate topographic guidance information.

Publication types

  • Research Support, Non-U.S. Gov't

MeSH terms

  • Amacrine Cells / metabolism
  • Animals
  • Ephrin-A2 / biosynthesis
  • Ephrin-A3 / metabolism
  • Ephrin-A5 / metabolism
  • Ephrins / metabolism*
  • Goldfish / physiology*
  • Nerve Crush
  • Nerve Regeneration / physiology*
  • Optic Nerve / pathology
  • Optic Nerve / physiology*
  • Optic Nerve Injuries* / pathology
  • Optic Nerve Injuries* / physiopathology
  • Retina / metabolism*
  • Retinal Ganglion Cells / metabolism
  • Time Factors
  • Up-Regulation

Substances

  • Ephrin-A2
  • Ephrin-A3
  • Ephrin-A5
  • Ephrins