Strong association between the GSTM1-null genotype and lung cancer in a Turkish population

Cancer Genet Cytogenet. 2003 Oct 15;146(2):125-9. doi: 10.1016/s0165-4608(03)00059-1.


Glutathione S-transferases are possibly related to the detoxification of many xenobiotics involved in the etiology of cancer. To investigate the role of the glutathione S-transferase M1 deletion (GSTM1-null) in lung cancer, the polymerase chain reaction was used to determine the GSTM1 genotypes of lung cancer patients (n=101) and hospital (n=206) in a Turkish population. The prevalence of the GSTM1-null genotype in the case group was 48%, compared to 18% in the control group, giving an odds ratio (OR) of 4.14 (95% confidence interval [CI]=2.36-7.27). The analysis of patients by histologic type of lung cancer (10% adenocarcinoma, 43% squamous cell carcinoma, 26% small cell carcinoma, and 11% large cell carcinoma) showed no association between histopathologic type of lung cancer and GSTM1-null genotype. When the interaction between the GSTM1-null genotype and smoking status was analyzed, among the 67 smokers, the GSTM1-null genotype was found in 37 (55%) with an OR of 2.58 (95% CI=1.00-6.73) indicating a significant association. However, no association was found between smoking exposure (<30 and > or =30 packs/year) and GSTM1-null genotype. We conclude that, in this study the null GSTM1 genotype is an independent risk factor for the development of lung cancer for Turkish population.

Publication types

  • Research Support, Non-U.S. Gov't

MeSH terms

  • Adult
  • Aged
  • Case-Control Studies
  • Female
  • Gene Deletion*
  • Genetic Predisposition to Disease
  • Genotype
  • Glutathione Transferase / genetics*
  • Humans
  • Lung Neoplasms / genetics*
  • Male
  • Middle Aged
  • Odds Ratio
  • Polymorphism, Genetic
  • Smoking
  • Turkey


  • Glutathione Transferase
  • glutathione S-transferase M1