Imazalil-cyclomaltoheptaose (beta-cyclodextrin) inclusion complex: preparation by supercritical carbon dioxide and 13C CPMAS and 1H NMR characterization

Carbohydr Res. 2003 Oct 10;338(21):2227-32. doi: 10.1016/s0008-6215(03)00358-6.

Abstract

An inclusion complex between imazalil (IMZ), a selected fungicide, and cyclomaltoheptaose (beta-cyclodextrin, betaCD) was obtained using supercritical fluid carbon dioxide. The best preparation conditions were determined, and the inclusion complex was investigated by means of 1H NMR spectroscopy in aqueous solution and 13C CPMAS NMR spectroscopy in the solid state. Information on the geometry of the betaCD/IMZ complex was obtained from ROESY spectroscopy, while the dynamics of the inclusion complex in the kilohertz range was obtained from the proton spin-lattice relaxation times in the rotating frame, T(1rho) (1H).

Publication types

  • Research Support, Non-U.S. Gov't

MeSH terms

  • Carbon Dioxide / chemistry
  • Carbon Isotopes / chemistry
  • Cyclodextrins / chemistry*
  • Imidazoles / chemistry*
  • Magnetic Resonance Spectroscopy
  • Molecular Structure
  • Protons
  • beta-Cyclodextrins*

Substances

  • Carbon Isotopes
  • Cyclodextrins
  • Imidazoles
  • Protons
  • beta-Cyclodextrins
  • Carbon Dioxide
  • enilconazole
  • betadex