G proteins

Trends Biochem Sci. 1992 Oct;17(10):383-7. doi: 10.1016/0968-0004(92)90005-t.


The family of heterotrimeric guanine nucleotide-binding regulatory proteins (G proteins) serves an essential role in transducing receptor-generated signals across the plasma membrane. Recent findings reveal unexpected functional roles for individual G protein subunits. Thus, GTP-binding alpha-subunits and the beta gamma-subunit complex can influence the activity of effector molecules independently or simultaneously, either synergistically or in opposition, to elicit a complex constellation of cellular events.

Publication types

  • Research Support, Non-U.S. Gov't
  • Research Support, U.S. Gov't, P.H.S.
  • Review

MeSH terms

  • Animals
  • Cell Membrane / physiology
  • GTP-Binding Proteins / chemistry
  • GTP-Binding Proteins / physiology*
  • Humans
  • Signal Transduction / physiology*


  • GTP-Binding Proteins