The Serum Response Element

Trends Biochem Sci. 1992 Oct;17(10):423-6. doi: 10.1016/0968-0004(92)90013-y.

Abstract

The promoters of many genes whose transcription is rapidly and transiently induced following growth factor or mitogen stimulation of susceptible cells contain a common regulatory element, the serum response element (SRE). As the transcription factors that bind the SRE and the signalling molecules that affect its activity are characterized in more detail, the major challenge is to elucidate the signalling pathways that link cell-surface receptors to the SRE, and to determine the mechanism by which signalling events modulate transcription factor activity.

Publication types

  • Review

MeSH terms

  • Animals
  • Base Sequence
  • DNA-Binding Proteins / physiology
  • Gene Expression Regulation / physiology
  • Humans
  • Molecular Sequence Data
  • Nuclear Proteins / physiology
  • Proto-Oncogene Proteins c-fos / genetics
  • Regulatory Sequences, Nucleic Acid / physiology*
  • Serum Response Factor
  • Signal Transduction / physiology
  • Transcription Factors / chemistry
  • Transcription Factors / physiology*

Substances

  • DNA-Binding Proteins
  • Nuclear Proteins
  • Proto-Oncogene Proteins c-fos
  • Serum Response Factor
  • Transcription Factors