Protein sorting in mitochondria

Trends Biochem Sci. 1992 Nov;17(11):453-9. doi: 10.1016/0968-0004(92)90487-t.


Most polypeptides that are imported into the mitochondrial matrix use a common translocation machinery. By contrast, proteins of the other mitochondrial compartments are imported by a variety of different mechanisms. Some of these proteins completely bypass the common translocation machinery, others use only the outer membrane components of this machinery, and still others use components of this machinery from both the outer and inner membranes. Import to the intermembrane space compartment provides examples of all three possibilities.

Publication types

  • Review

MeSH terms

  • Amino Acid Sequence
  • Biological Transport
  • Cytochromes / metabolism
  • Intracellular Membranes / metabolism
  • Mitochondria / metabolism*
  • Molecular Sequence Data
  • Protein Processing, Post-Translational
  • Protein Sorting Signals / metabolism
  • Proteins / metabolism*


  • Cytochromes
  • Protein Sorting Signals
  • Proteins