The ATP-dependent glutathione S-conjugate export pump

Trends Biochem Sci. 1992 Nov;17(11):463-8. doi: 10.1016/0968-0004(92)90489-v.


The ATP-dependent glutathione S-conjugate export pump (GS-X pump) plays a physiologically important role as a member of the 'phase III' system in xenobiotic metabolism as well as in the release of biologically active endogenous substances from cells. In addition, this export pump is potentially involved in the modulation of the antiproliferative action of certain antitumor agents.

Publication types

  • Review

MeSH terms

  • Adenosine Triphosphate / physiology*
  • Animals
  • Biological Transport, Active
  • Cell Division
  • Cell Membrane / metabolism
  • Glutathione / metabolism*
  • Humans
  • Neoplasms / pathology
  • Xenobiotics / metabolism


  • Xenobiotics
  • Adenosine Triphosphate
  • Glutathione