Primary B cell lymphoma of the penis: successful treatment with organ preservation

Arch Androl. 2003 Nov-Dec;49(6):467-70. doi: 10.1080/01485010390219953.


Malignant lymphoma uncommonly manifests in the genitourinary tract. Primary penile lymphoma is extremely rare. A 77-year-old male presented with primary malignant B-cell lymphoma of the penis with the chief complaint of a painless and itching nodule on the penile glans for more than 2 months. The pathologic examination with immunohistochemical stain of penile biopsy revealed malignant B cell lymphoma, mixed cellular type. The physical examination and the computed tomography scan of chest, abdomen, and pelvis showed no evidence of superficial, thoracic, abdominal, or pelvic lymphadenopathy. This case was treated with local excision and systemic chemotherapy with good cosmetic and functional results. There was absence of recurrence 16 months after therapy.

Publication types

  • Case Reports

MeSH terms

  • Aged
  • Antineoplastic Combined Chemotherapy Protocols / therapeutic use
  • Biomarkers, Tumor / analysis
  • Combined Modality Therapy
  • Cyclophosphamide / administration & dosage
  • Humans
  • Immunohistochemistry
  • Lymphoma, B-Cell / chemistry
  • Lymphoma, B-Cell / pathology*
  • Lymphoma, B-Cell / therapy
  • Male
  • Penile Neoplasms / chemistry
  • Penile Neoplasms / pathology*
  • Penile Neoplasms / therapy
  • Prednisolone / administration & dosage
  • Treatment Outcome
  • Vincristine / administration & dosage


  • Biomarkers, Tumor
  • Vincristine
  • Cyclophosphamide
  • Prednisolone