Collagenolytic proteases from bacteria

Appl Microbiol Biotechnol. 2004 Feb;63(5):520-6. doi: 10.1007/s00253-003-1442-0. Epub 2003 Oct 11.


Collagen degradation occurs during various physiological and pathological conditions. However, only a limited number of proteases with unique characteristics can trigger collagen degradation. Until recently, practical applications of collagenolytic proteases from bacteria had not been considered because their functions in bacteria are closely related to pathogenicity. However, bacterial collagenolytic proteases have many interesting and useful features. This review focuses on the collagenolytic proteases from bacteria, in particular their molecular properties and practical applications.

Publication types

  • Review

MeSH terms

  • Bacteria / enzymology*
  • Binding Sites
  • Catalytic Domain
  • Collagenases / chemistry*
  • Collagenases / metabolism*
  • Collagenases / therapeutic use
  • Cysteine Endopeptidases / chemistry
  • Cysteine Endopeptidases / metabolism
  • Metalloendopeptidases / metabolism
  • Molecular Weight
  • Serine Endopeptidases / chemistry
  • Serine Endopeptidases / metabolism


  • Serine Endopeptidases
  • Cysteine Endopeptidases
  • Collagenases
  • Metalloendopeptidases
  • thimet oligopeptidase