Death and the retrovirus

Trends Mol Med. 2003 Oct;9(10):409-13. doi: 10.1016/j.molmed.2003.08.008.

Abstract

A flurry of new papers has shown that HIV reverse transcription is vulnerable to G-->A hypermutation. Apparently, cytidine bases in nascent DNA synthesis are lethally edited by the host cell molecule apolipoprotein B editing complex protein (APOBEC) 3G. This death mechanism is circumvented by the HIV viral infectivity factor protein, which prevents APOBEC3G from entering the virion.

Publication types

  • Review

MeSH terms

  • APOBEC-3G Deaminase
  • Base Sequence
  • Cytidine Deaminase
  • Gene Products, vif / genetics
  • Gene Products, vif / physiology
  • HIV / genetics
  • Hepatitis B virus / genetics
  • Humans
  • Mutagenesis / genetics*
  • Nucleoside Deaminases
  • Proteins / antagonists & inhibitors
  • Proteins / metabolism*
  • Repressor Proteins
  • Retroviridae / genetics*
  • vif Gene Products, Human Immunodeficiency Virus

Substances

  • Gene Products, vif
  • Proteins
  • Repressor Proteins
  • vif Gene Products, Human Immunodeficiency Virus
  • Nucleoside Deaminases
  • APOBEC-3G Deaminase
  • APOBEC3G protein, human
  • Cytidine Deaminase