[Preclinical prognosis of pyracetam and picamilon safety based on acute toxicity data]

Eksp Klin Farmakol. 2003 Jul-Aug;66(4):43-6.
[Article in Russian]


A comparative acute toxicity test of the nootropic drugs piracetam and picamilon was performed on rats. The study was based on the principles of integral evaluation of the drug effect upon the functional and behavioral state of animals. It was found that the conventional therapeutic index does not coincide with the actual therapeutic activity range. Piracetam and picamilon, while exhibiting significantly different toxicity, are characterized by approximately equal ranges of the therapeutic activity.

Publication types

  • English Abstract

MeSH terms

  • Animals
  • Drug Evaluation, Preclinical
  • Female
  • Lethal Dose 50
  • Male
  • Nootropic Agents / toxicity*
  • Piracetam / toxicity*
  • Rats
  • Toxicity Tests, Acute
  • gamma-Aminobutyric Acid / analogs & derivatives
  • gamma-Aminobutyric Acid / toxicity*


  • Nootropic Agents
  • nicotinoyl-GABA
  • gamma-Aminobutyric Acid
  • Piracetam