Autophagy in yeast: a TOR-mediated response to nutrient starvation

Curr Top Microbiol Immunol. 2004;279:73-84. doi: 10.1007/978-3-642-18930-2_5.

Abstract

TOR plays a key role in cell growth and cell-cycle progression, but in addition recent studies have shown that TOR is also involved in the regulation of a number of molecular processes associated with nutrient deprivation, such as autophagy. In budding yeast, TOR negatively regulates activation of Apg1 protein kinase, which is essential for the induction of autophagy. This review describes recent research in this field and the mechanism by which TOR mediates induction of autophagy.

Publication types

  • Review

MeSH terms

  • Adaptor Proteins, Signal Transducing
  • Autophagy-Related Protein 5
  • Autophagy-Related Protein 8 Family
  • Autophagy-Related Proteins
  • DNA-Binding Proteins / metabolism
  • Glutathione Peroxidase
  • Microtubule-Associated Proteins / metabolism
  • Phosphatidylinositol 3-Kinases / metabolism*
  • Phosphotransferases (Alcohol Group Acceptor) / metabolism*
  • Prions / metabolism
  • Protein Kinases / metabolism
  • Protein Serine-Threonine Kinases / metabolism
  • Saccharomyces cerevisiae / enzymology*
  • Saccharomyces cerevisiae / metabolism
  • Saccharomyces cerevisiae Proteins / metabolism*
  • Ubiquitin-Protein Ligases

Substances

  • ATG5 protein, S cerevisiae
  • ATG8 protein, S cerevisiae
  • Adaptor Proteins, Signal Transducing
  • Autophagy-Related Protein 5
  • Autophagy-Related Protein 8 Family
  • Autophagy-Related Proteins
  • DNA-Binding Proteins
  • Microtubule-Associated Proteins
  • Prions
  • Saccharomyces cerevisiae Proteins
  • TAP42 protein, S cerevisiae
  • Glutathione Peroxidase
  • URE2 protein, S cerevisiae
  • Ubiquitin-Protein Ligases
  • Protein Kinases
  • ATG1 protein, S cerevisiae
  • Phosphotransferases (Alcohol Group Acceptor)
  • SNF1-related protein kinases
  • TOR1 protein, S cerevisiae
  • Protein Serine-Threonine Kinases