Cell motility: deaf Drosophila keep the beat

Curr Biol. 2003 Oct 14;13(20):R796-8. doi: 10.1016/j.cub.2003.09.047.

Abstract

Intraflagellar transport is involved in the assembly of cilia and eukaryotic flagella. Two recent studies have shown that defects in intraflagellar transport prevent assembly of sensory cilia in Drosophila, leaving the fly deaf and uncoordinated. Surprisingly, the mutant sperm flagella have normal structure and motility.

Publication types

  • Review

MeSH terms

  • Animals
  • Biological Transport, Active
  • Cell Movement / physiology*
  • Chlamydomonas / physiology
  • Cilia / metabolism*
  • Cilia / physiology
  • Drosophila / cytology
  • Drosophila / physiology*
  • Flagella / metabolism*
  • Flagella / physiology
  • Male
  • Neurons, Afferent / cytology
  • Plant Proteins
  • Protozoan Proteins / metabolism
  • Spermatozoa / physiology*

Substances

  • IFT88 protein, Chlamydomonas
  • Plant Proteins
  • Protozoan Proteins