Anxiolytic-like effect of succinic acid in mice

Life Sci. 2003 Nov 7;73(25):3257-64. doi: 10.1016/j.lfs.2003.06.017.


The putative anxiolytic activity of succinic acid was examined in male mice by using a number of experimental paradigms of anxiety and compared with that of the known anxiolytic compound diazepam. Use of the elevated plus-maze test revealed that diazepam (1.0, 2.0 and 4.0 mg/kg, PO) or succinic acid (3.0 or 6.0 mg/kg, PO) increased the percentage of entries into open arms and of time spent on open arms. In novel food consumption test, succinic acid (3.0, 6.0, and 12.0 mg/kg, IP) caused significant increases in food intake during 5 min when compared with the vehicle. In the stress-induced hyperthermia test, 40 min after drug administration rectal temperature was measured, succinic acid at dose of 1.5 mg/kg, inhibited stress-induced hyperthermia. Thus, these findings indicated that, in contrast with diazepam, succinic acid exhibits anxiolytic-like effect.

MeSH terms

  • Animals
  • Anti-Anxiety Agents / pharmacology*
  • Anxiety / prevention & control*
  • Behavior, Animal / drug effects*
  • Body Temperature / drug effects
  • Diazepam / pharmacology
  • Dose-Response Relationship, Drug
  • Eating / drug effects
  • Hyperthermia, Induced
  • Male
  • Maze Learning / drug effects
  • Mice
  • Succinic Acid / pharmacology*


  • Anti-Anxiety Agents
  • Succinic Acid
  • Diazepam