A modulatory role for facial expressions in prosopagnosia

Proc Natl Acad Sci U S A. 2003 Oct 28;100(22):13105-10. doi: 10.1073/pnas.1735530100. Epub 2003 Oct 15.

Abstract

Brain-damaged patients experience difficulties in recognizing a face (prosopagnosics), but they can still recognize its expression. The dissociation between these two face-related skills has served as a keystone of models of face processing. We now report that the presence of a facial expression can influence face identification. For normal viewers, the presence of a facial expression influences performance negatively, whereas for prosopagnosic patients, it improves performance dramatically. Accordingly, although prosopagnosic patients show a failure to process the facial configuration in the interest of face identification, that ability returns when the face shows an emotional expression. Accompanying brain-imaging results indicate activation in brain areas (amygdala, superior temporal sulcus, parietal cortex) outside the occipitotemporal areas normally activated for face identification and lesioned in these patients. This finding suggests a modulatory role of these areas in face identification that is independent of occipitotemporal face areas.

Publication types

  • Research Support, U.S. Gov't, P.H.S.

MeSH terms

  • Adult
  • Aged
  • Brain / pathology*
  • Brain Mapping
  • Facial Expression*
  • Housing
  • Humans
  • Magnetic Resonance Imaging
  • Male
  • Middle Aged
  • Prosopagnosia / psychology*
  • Reference Values