Design and total synthesis of a superior family of epothilone analogues, which eliminate xenograft tumors to a nonrelapsable state

Angew Chem Int Ed Engl. 2003 Oct 13;42(39):4762-7. doi: 10.1002/anie.200352361.
No abstract available

Publication types

  • Research Support, Non-U.S. Gov't
  • Research Support, U.S. Gov't, P.H.S.

MeSH terms

  • Animals
  • Antineoplastic Agents / chemical synthesis*
  • Antineoplastic Agents / pharmacology
  • Antineoplastic Agents / therapeutic use
  • Body Weight
  • Drug Screening Assays, Antitumor
  • Epothilones / chemical synthesis*
  • Epothilones / pharmacology
  • Epothilones / therapeutic use
  • Humans
  • Mice
  • Mice, Nude
  • Models, Chemical
  • Neoplasm Transplantation
  • Neoplasms / drug therapy
  • Neoplasms / metabolism*
  • Paclitaxel / pharmacology
  • Paclitaxel / therapeutic use
  • Structure-Activity Relationship
  • Tumor Cells, Cultured

Substances

  • Antineoplastic Agents
  • Epothilones
  • Paclitaxel