Pathophysiological aspects of diverticular disease of colon and role of large bowel motility

World J Gastroenterol. 2003 Oct;9(10):2140-2. doi: 10.3748/wjg.v9.i10.2140.


Colonic diverticular disease (diverticulosis) is one of the most common gastrointestinal disorders in Western countries. This disorder is strictly related to aging and fibre intake, and still bears a discrete amount of morbidity. Numerous etiological co-factors have to date been implicated in the pathogenesis of the disease, yet the supporting evidence is still far from absolute. The present review considers the pathophysiology of colonic diverticular disease, with a special emphasis on factors related to abnormal colonic motility.

Publication types

  • Review

MeSH terms

  • Colon / physiopathology*
  • Diverticulosis, Colonic / physiopathology*
  • Gastrointestinal Motility / physiology*
  • Humans