Neonatal hemochromatosis

Gastroenterol Clin North Am. 2003 Sep;32(3):877-89, vi-vii. doi: 10.1016/s0889-8553(03)00050-5.


Neonatal hemochromatosis is a rare gestational condition in which iron accumulates in the fetal tissues in a distribution like that seen in hereditary hemochromatosis. Extensive liver damage is the dominant clinical feature, with late fetal loss or early neonatal death. NH recurs within sibships at a rate higher than that predicted for simple Mendelian autosomal-recessive inheritance, possibly suggesting the role of a maternal factor. Immunomodulation during pregnancy at risk appears to lessen the severity of disease.

Publication types

  • Review

MeSH terms

  • Female
  • Genes, Recessive
  • Genetic Counseling
  • Hemochromatosis* / diagnosis
  • Hemochromatosis* / etiology
  • Hemochromatosis* / pathology
  • Hemochromatosis* / therapy
  • Humans
  • Infant, Newborn
  • Iron / metabolism
  • Liver / metabolism
  • Liver / pathology
  • Liver Failure / etiology*
  • Maternal-Fetal Exchange
  • Phenotype
  • Pregnancy
  • Prenatal Diagnosis
  • Prognosis


  • Iron