Biliary atresia

Gastroenterol Clin North Am. 2003 Sep;32(3):891-911. doi: 10.1016/s0889-8553(03)00049-9.


BA is a rare disease of unclear etiology; nevertheless, its impact in the field of pediatric hepatology is significant. It is the most common surgically correctable cause of neonatal cholestasis and is the most common pediatric disease referred for liver transplantation. Little progress has been made with regard to improving outcome or understanding its pathogenesis in the past decade. Fortunately, however, a national, government-sponsored collaborative endeavor has begun that will hopefully make a significant impact upon the progress of designing new treatments for BA and develop a better understanding of its pathogenesis.

Publication types

  • Review

MeSH terms

  • Animals
  • Bile Ducts, Extrahepatic / abnormalities
  • Biliary Atresia* / diagnosis
  • Biliary Atresia* / etiology
  • Biliary Atresia* / pathology
  • Biliary Atresia* / therapy
  • Calcium-Binding Proteins
  • Hepatic Artery / abnormalities
  • Humans
  • Immune System Diseases / complications
  • Intercellular Signaling Peptides and Proteins
  • Membrane Proteins
  • Mutation
  • Portal Vein / abnormalities
  • Portoenterostomy, Hepatic
  • Postoperative Care
  • Proteins / genetics
  • Serrate-Jagged Proteins
  • Toxins, Biological / toxicity
  • Transcription Factors*
  • Virus Diseases / complications


  • Calcium-Binding Proteins
  • INVS protein, human
  • Intercellular Signaling Peptides and Proteins
  • Membrane Proteins
  • Proteins
  • Serrate-Jagged Proteins
  • Toxins, Biological
  • Transcription Factors