Cyclic vomiting syndrome: a brain-gut disorder

Gastroenterol Clin North Am. 2003 Sep;32(3):997-1019. doi: 10.1016/s0889-8553(03)00045-1.


Despite the "black box" surrounding CVS, the authors' understanding of this clinical entity has advanced substantially in the last decade as a result of an international interdisciplinary clinical and research effort. Although CVS is now recognized as a unique clinical entity, patients still undergo innumerable hospitalizations and diagnostic tests. Although controlled therapeutic studies are lacking, reasonably effective empiric approaches have been developed by trial and error using anti-migraine, anti-emetic, and anti-epileptic regimens. The ongoing investigations of migraine mechanisms through NMR spectroscopy, mitochondrial DNA mutations and cellular energetics, corticotropin-releasing factor and gastric motility, and brainstem regulation of autonomic function may lead to breakthroughs in the understanding of and new therapies for CVS in the next decade.

Publication types

  • Research Support, Non-U.S. Gov't
  • Research Support, U.S. Gov't, P.H.S.
  • Review

MeSH terms

  • Diagnosis, Differential
  • Humans
  • Migraine Disorders* / diagnosis
  • Migraine Disorders* / etiology
  • Migraine Disorders* / therapy
  • Periodicity
  • Recurrence
  • Syndrome
  • Vomiting* / diagnosis
  • Vomiting* / etiology
  • Vomiting* / therapy