The hemodynamic effects of acute myocardial ischemia and reperfusion in Clawn miniature pigs

Exp Anim. 2003 Jul;52(4):335-8. doi: 10.1538/expanim.52.335.


Acute myocardial ischemia was induced by occluding the LAD in Clawn miniature pigs. Eight pigs (group 1) were subjected to 6 h ischemia and nine pigs (group 2) were subjected to 20 min ischemia, followed by reperfusion for 340 min. Three animals of the group 1 died due to ventricular fibrillation after occlusion and in group 2, four animals died due to the arrhythmia after reperfusion. Though the ischemic area of group 2 (15.6% of the ventricle) was narrower than that of group 1 (21.7%), the survival rate was lower. We supposed that ischemia-reperfusion injuries were strongly connected with the hemodynamics of group 2. Clawn miniature pigs are useful experimental animals for myocardial ischemic researches.

MeSH terms

  • Animals
  • Hemodynamics / physiology*
  • Male
  • Myocardial Reperfusion Injury / physiopathology*
  • Swine, Miniature / physiology*