Esophageal atresia and tracheoesophageal fistula in two infants born to hyperthyroid women receiving methimazole (Tapazol) during pregnancy

Am J Med Genet. 1992 Sep 15;44(2):200-2. doi: 10.1002/ajmg.1320440216.


We report on 2 newborn infants with esophageal atresia and tracheoesophageal fistula (EA + TEF) born to hyperthyroid mothers receiving methimazole (Tapazol) before and during their entire pregnancies. Both mothers were euthyroid during gestation and developed hydramnios diagnosed during weeks 34 and 33 of gestation. Premature delivery (36.2 weeks of gestation) occurred in one case, and both newborn infants were small for date with palpable goiter; one of them had other associated malformations. Hypothyroidism was diagnosed by laboratory tests in both cases. Corrective surgery was undertaken, but both newborn infants developed septicemia and renal insufficiency and died in the first week of life. The EA + TEF and a normally placed enlarged thyroid gland were confirmed at necropsy. These cases represent a previously unreported example of the association of maternal ingestion of methimazole during pregnancy and EA + TEF.

Publication types

  • Case Reports

MeSH terms

  • Abnormalities, Drug-Induced
  • Adult
  • Esophageal Atresia / chemically induced*
  • Female
  • Humans
  • Hyperthyroidism / complications
  • Hyperthyroidism / drug therapy
  • Infant, Newborn
  • Male
  • Maternal-Fetal Exchange
  • Methimazole / adverse effects*
  • Pregnancy
  • Pregnancy Complications / drug therapy
  • Tracheoesophageal Fistula / chemically induced*


  • Methimazole