A pilot study of screening for neuroblastoma in the north of England

Am J Pediatr Hematol Oncol. 1992 Nov;14(4):337-41.


A pilot study has been carried out to assess the feasibility of screening for neuroblastoma in 6-month-old infants in the north of England. A total of 20,829 infants were screened. Two true-positive cases were found, along with eight false-positive and three false-negative cases. It was shown that the concentrations of catecholamine metabolites in the urine are dependent on the creatinine content; centiles have been established to allow this relationship to be taken into account. Five of the eight false-positive cases would have been correctly assessed as normal if the new centiles had been used. Preliminary results lend support to the need for a well-designed study of neuroblastoma screening to be carried out, with death from this disease as the only end point.

Publication types

  • Research Support, Non-U.S. Gov't

MeSH terms

  • England / epidemiology
  • Female
  • Homovanillic Acid / urine
  • Humans
  • Infant
  • Male
  • Mass Screening / methods*
  • Neuroblastoma / diagnosis*
  • Neuroblastoma / mortality
  • Neuroblastoma / urine
  • Pilot Projects
  • Predictive Value of Tests
  • Vanilmandelic Acid / urine


  • Vanilmandelic Acid
  • Homovanillic Acid