Skip to main page content
Access keys NCBI Homepage MyNCBI Homepage Main Content Main Navigation
Comparative Study
, 22 (11), 651-5

Voriconazole Salvage Treatment of Invasive Candidiasis

Affiliations
Comparative Study

Voriconazole Salvage Treatment of Invasive Candidiasis

L Ostrosky-Zeichner et al. Eur J Clin Microbiol Infect Dis.

Abstract

Data on the salvage treatment of invasive candidiasis with voriconazole in 52 patients intolerant of other antifungal agents or with infection refractory to other antifungal agents were analyzed. Patients had received a mean of two previous antifungal agents (range, 1-4 agents), and 83% had received an azole. Manifestations of invasive candidiasis included candidemia (37%), disseminated disease (25%), and infection of other sites (38%). The median duration of voriconazole therapy was 60 days (range, 1-314 days). The overall rate of response was 56% (95%CI, 41-70), with the following response rates observed for individual Candida species: Candida albicans, 44% (20-70); Candida glabrata, 38% (14-68); Candida krusei, 70% (35-93); Candida tropicalis, 67% (30-93); and other Candida spp., 100% (40-100). The response rate in patients who had failed previous azole therapy was 58% (42-73). Common adverse events (~20%) included nausea and emesis, abnormal liver enzymes, and visual disturbances. Serious adverse events occurred in four patients, and nine patients died. Voriconazole has promise as a salvage agent for the treatment of invasive candidiasis, even in the settings of previous azole therapy and infection due to Candida krusei.

Similar articles

See all similar articles

Cited by 25 PubMed Central articles

See all "Cited by" articles

References

    1. Antimicrob Agents Chemother. 2003 Oct;47(10):3149-54 - PubMed
    1. Eur J Med Res. 2002 May 31;7(5):183-91 - PubMed
    1. Diagn Microbiol Infect Dis. 1999 Sep;35(1):19-25 - PubMed
    1. Clin Infect Dis. 2001 Nov 1;33(9):1447-54 - PubMed
    1. Transpl Infect Dis. 1999 Dec;1(4):237-46 - PubMed

Publication types

MeSH terms

LinkOut - more resources

Feedback