Evaluation of immune complexes after immunotherapy with wheat flour in bakers' asthma

Ann Allergy. 1992 Nov;69(5):441-4.


Inhalant food allergy has been described many times in literature, but double-blind clinical trials to support successful hyposensitization to these allergens has seldom been reported. Some authors have suspected that certain adverse reactions after immunotherapy may be mediated by immune complexes. Furthermore, the FDA does not recommend injection therapy with food extracts. We present a study on the detection of adverse effects after immunotherapy with an inhalant food (wheat flour) in a double-blind clinical trial in 26 patients with bakers' asthma. We investigated the presence of circulating immune complexes (CICs) after 2 years of treatment with hyposensitization to wheat flour.

Publication types

  • Clinical Trial
  • Controlled Clinical Trial
  • Randomized Controlled Trial

MeSH terms

  • Antigen-Antibody Complex / analysis*
  • Antigen-Antibody Complex / blood
  • Asthma / immunology*
  • Asthma / therapy*
  • Double-Blind Method
  • Enzyme-Linked Immunosorbent Assay
  • Erythema / etiology
  • Flour
  • Humans
  • Hypersensitivity, Immediate / blood
  • Immunotherapy* / adverse effects
  • Occupational Diseases / immunology*
  • Occupational Diseases / therapy*
  • Plant Extracts / administration & dosage
  • Triticum


  • Antigen-Antibody Complex
  • Plant Extracts