N-3 substituted TSAO derivatives as a probe to explore the dimeric interface of HIV-1 reverse transcriptase

Nucleosides Nucleotides Nucleic Acids. May-Aug 2003;22(5-8):947-9. doi: 10.1081/NCN-120022692.
No abstract available

Publication types

  • Research Support, Non-U.S. Gov't

MeSH terms

  • Binding Sites
  • Dimerization
  • HIV Reverse Transcriptase / metabolism*
  • HIV-1 / physiology*
  • Models, Molecular
  • Molecular Structure
  • RNA-Directed DNA Polymerase / metabolism
  • Reverse Transcriptase Inhibitors / chemistry*
  • Reverse Transcriptase Inhibitors / pharmacology
  • Spiro Compounds / chemistry
  • Spiro Compounds / pharmacology
  • Structure-Activity Relationship
  • Thymidine / analogs & derivatives*
  • Thymidine / chemistry
  • Thymidine / pharmacology
  • Uridine / analogs & derivatives
  • Virus Replication / drug effects

Substances

  • Reverse Transcriptase Inhibitors
  • Spiro Compounds
  • reverse transcriptase, Human immunodeficiency virus 2
  • HIV Reverse Transcriptase
  • RNA-Directed DNA Polymerase
  • Thymidine
  • TSAO-T
  • Uridine