Comparison of arterial spin-labeling techniques and dynamic susceptibility-weighted contrast-enhanced MRI in perfusion imaging of normal brain tissue

Invest Radiol. 2003 Nov;38(11):712-8. doi: 10.1097/01.rli.0000084890.57197.54.


Objectives: To evaluate relative cerebral blood flow (rCBF) in normal brain tissue using arterial spin-labeling (ASL) methods and first-pass dynamic susceptibility-weighted contrast-enhanced (DSC) magnetic resonance imaging (MRI).

Methods: Sixty-two patients with brain metastases were examined on a 1.5 T-system up to 6 times during routine follow-up after stereotactic radiosurgery. Perfusion values in normal gray and white matter were measured using the ASL techniques ITS-FAIR in 38 patients, Q2TIPS in 62 patients, and the first-pass DSC echo-planar (EPI) MRI after bolus administration of gadopentetate dimeglumine in 42 patients. Precision of the ASL sequences was tested in follow-up examinations in 10 healthy volunteers.

Results: Perfusion values in normal brain tissue obtained by all sequences correlated well by calculating Pearson's correlation coefficients (P < 0.0001) and remained unchanged after stereotactic radiosurgery as shown by analysis of variance (P > 0.05).

Conclusion: Both ASL and DSC EPI MRI yield highly comparable perfusion values in normal brain tissue.

Publication types

  • Comparative Study
  • Evaluation Study

MeSH terms

  • Adult
  • Aged
  • Brain / blood supply*
  • Brain Neoplasms / blood supply*
  • Brain Neoplasms / secondary*
  • Brain Neoplasms / surgery
  • Cerebrovascular Circulation*
  • Contrast Media
  • Female
  • Gadolinium DTPA
  • Humans
  • Image Enhancement / methods*
  • Magnetic Resonance Imaging / methods*
  • Male
  • Middle Aged
  • Radiosurgery


  • Contrast Media
  • Gadolinium DTPA