Association of newer diastolic function parameters with age in healthy subjects: a population-based study

J Am Soc Echocardiogr. 2003 Oct;16(10):1049-56. doi: 10.1016/S0894-7317(03)00516-9.


Objectives: We sought to determine if newer Doppler diastolic function parameters are associated with age and to define age-stratified reference ranges for these parameters in a population-based setting.

Background: Although newer Doppler parameters aid in the evaluation of diastolic function and filling pressures, age-specific reference ranges are poorly described.

Methods: Randomly selected residents of Olmsted County, Minn, age >/= 45 years were studied (n = 2042) prospectively. Those without a history of cardiovascular disease or abnormal 2-dimensional echocardiograms were selected. Measured parameters included the transmitral early (E) and late (A) filling velocities at rest and with Valsalva, A duration, pulmonary venous atrial reversal duration, lateral and septal early diastolic mitral annular velocities, E/lateral early diastolic mitral annular velocity, E/septal early diastolic mitral annular velocity, and the index of left ventricular myocardial performance.

Results: A total of 1012 subjects met the inclusion criteria. Both A duration (r = 0.18, P <.001) and pulmonary venous atrial reversal duration (r = 0.28, P <.001) were longer in older subjects, whereas their difference showed a marginal correlation with age (r = 0.07, P =.036). The E/A ratio at peak Valsalva correlated with age (r = -0.54, P <.001) whereas the change in E/A with Valsalva (corrected for E-A fusion) showed a marginal correlation with age (r = 0.08, P =.032). Both E/lateral early diastolic mitral annular velocity (r = 0.39, P <.001) and E/septal early diastolic mitral annular velocity (r = 0.27, P <.001) increased with age. Left ventricular myocardial performance showed a marginal correlation with age (r = 0.08, P =.014). Age specific reference ranges (median, 5th and 95th percentiles) for all parameters are provided.

Conclusions: All newer Doppler diastolic function parameters showed a variable but significant correlation with age. Age-specific reference values will aid in the interpretation of diastolic function parameters.

Publication types

  • Clinical Trial
  • Comparative Study
  • Randomized Controlled Trial
  • Research Support, Non-U.S. Gov't
  • Research Support, U.S. Gov't, P.H.S.

MeSH terms

  • Age Factors
  • Aged
  • Blood Flow Velocity / physiology
  • Blood Pressure / physiology
  • Cross-Sectional Studies
  • Diastole / physiology
  • Echocardiography, Doppler
  • Feasibility Studies
  • Female
  • Heart Atria / diagnostic imaging
  • Heart Ventricles / diagnostic imaging
  • Humans
  • Male
  • Middle Aged
  • Minnesota
  • Mitral Valve / diagnostic imaging
  • Mitral Valve / physiology
  • Prospective Studies
  • Randomized Controlled Trials as Topic
  • Reference Values
  • Sex Factors
  • Statistics as Topic
  • Stroke Volume / physiology
  • Systole / physiology
  • Valsalva Maneuver
  • Ventricular Function
  • Ventricular Function, Left / physiology*