Hematologic abnormalities in severe neonatal necrotizing enterocolitis: 25 years later

Pamela J Kling; John J Hutter

doi:10.1038/sj.jp.7210983

Hematologic abnormalities in severe neonatal necrotizing enterocolitis: 25 years later

J Perinatol. 2003 Oct;23(7):523-30. doi: 10.1038/sj.jp.7210983.

Authors

Pamela J Kling¹, John J Hutter

Affiliation

¹ Department of Pediatrics, University of Wisconsin, 6 Center Meriter Hospital, 202 South Park Street, Madison, WI 53715, USA.

PMID: 14566346
DOI: 10.1038/sj.jp.7210983

Abstract

Necrotizing enterocolitis (NEC), the most common surgical emergency in newborns, remains a therapeutic challenge for clinicians. The hematological manifestations associated with NEC were first described 25 years ago. This review discusses current knowledge of the pathophysiology involved in disturbances in megakaryocytopoiesis, coagulation, leukopoiesis, and erythropoiesis that accompany the clinical entity NEC. The discussion includes current understanding of and potential strategies for treating the hematopoietic disturbances that occur secondary to NEC.

Publication types

Research Support, Non-U.S. Gov't
Research Support, U.S. Gov't, P.H.S.
Review

MeSH terms

Enterocolitis, Necrotizing / complications*
Hematologic Diseases / etiology*
Humans
Infant, Newborn

Grants and funding

HD 26013/HD/NICHD NIH HHS/United States