[Pathogenetic aspectics of nephrotic syndrome]

Internist (Berl). 2003 Sep;44(9):1075-82. doi: 10.1007/s00108-003-1031-4.
[Article in German]


Nephrotic syndrome is characterized by protein loss in the urine, hypoalbuminemia, hyperlipidemia and edema. Several diseases cause a nephrotic syndrome, as they damage the glomerular podocytes. These specialized epithelial cells, together with endothelial cells of the glomerular capillaries and the basal membrane, form a filter that retains plasma proteins in the circulation. A disturbance of this filter causes proteinuria. The three most common primary glomerular diseases are minimal change, membranous glomerulonephritis, and the primary focal segmental glomerulosclerosis. The familiar forms are rare; however, the identification of the relevant gene defects has greatly advanced our understanding of podocyte function as well as the pathogenesis of nephrotic syndrome.

Publication types

  • English Abstract
  • Review

MeSH terms

  • Gene Expression Regulation
  • Genetic Predisposition to Disease / genetics
  • Humans
  • Intracellular Signaling Peptides and Proteins
  • Kidney Glomerulus / metabolism*
  • Kidney Glomerulus / pathology*
  • Membrane Proteins / genetics*
  • Membrane Proteins / metabolism*
  • Nephrotic Syndrome / genetics*
  • Nephrotic Syndrome / metabolism*
  • Nephrotic Syndrome / pathology
  • Proteins / genetics*
  • Proteins / metabolism*


  • Intracellular Signaling Peptides and Proteins
  • Membrane Proteins
  • NPHS2 protein
  • Proteins
  • nephrin