The movement of solutes and cells across tight junctions

Ann N Y Acad Sci. 1992;664:47-60. doi: 10.1111/j.1749-6632.1992.tb39748.x.


The TJ is a highly dynamic rate-limiting barrier for passive transepithelial solute flow. It is not only physiologically regulated but is modulated in various disease states as well. Such modulations occur as a result of epithelial cell interactions with immune cells or immune cell products and thus epithelial barrier function appears to be regulated in disease states.

Publication types

  • Research Support, U.S. Gov't, P.H.S.
  • Review

MeSH terms

  • Abscess / metabolism
  • Animals
  • Humans
  • Intercellular Junctions / metabolism*
  • Intercellular Junctions / physiology
  • Intestinal Mucosa / metabolism*
  • Intestines / ultrastructure
  • Neutrophils / physiology
  • Permeability