Total knee arthroplasty (TKA) dramatically decreases pain and improves mobility and quality of life. However, little has been reported on its effect on driving ability in the early postoperative period. This prospective study was conducted to compare preoperative and postoperative brake response times (BRTs) in patients undergoing TKA for osteoarthritis. The results showed that patients returned to preoperative BRT as early as 3 weeks after surgery, and at 9 weeks after surgery, BRTs were significantly improved over baseline. Based on BRT analysis patients undergoing TKA may be allowed to return to driving 6 weeks after surgery.