Aphrodisiac activity of 50% ethanolic extracts of Myristica fragrans Houtt. (nutmeg) and Syzygium aromaticum (L) Merr. & Perry. (clove) in male mice: a comparative study

BMC Complement Altern Med. 2003 Oct 20;3:6. doi: 10.1186/1472-6882-3-6.

Abstract

Background: Spices are considered as sexual invigorators in the Unani System of Medicine. In order to explore the sexual function improving effect of Myristica fragrans Houtt. (nutmeg) and Syzygium aromaticum (L) Merr. & Perry. (clove) an experimental study was conducted in normal male mice.

Methods: The extracts (50% ethanolic) of nutmeg and clove were administered (500 mg/kg; p.o.) to different groups of male Swiss mice. Mounting behaviour, mating performance, and general short term toxicity of the test drugs were determined and compared with the standard drug Penegra (Sildenafil citrate).

Results: The extracts of the nutmeg and clove were found to stimulate the mounting behaviour of male mice, and also to significantly increase their mating performance. The drugs were devoid of any conspicuous general short term toxicity.

Conclusion: The extracts (50% ethanolic) of nutmeg and clove enhanced the sexual behaviour of male mice.

Publication types

  • Comparative Study

MeSH terms

  • Administration, Oral
  • Analysis of Variance
  • Animals
  • Aphrodisiacs / pharmacology*
  • Aphrodisiacs / toxicity
  • Female
  • Male
  • Mice
  • Myristica*
  • Plant Extracts / pharmacology*
  • Plant Extracts / toxicity
  • Seeds
  • Sex Factors
  • Sexual Behavior, Animal / drug effects*
  • Syzygium*
  • Toxicity Tests, Acute

Substances

  • Aphrodisiacs
  • Plant Extracts