The level of pre-heparin serum lipoprotein lipase mass at different stages of pregnancy

Clin Chim Acta. 2003 Nov;337(1-2):153-6. doi: 10.1016/j.cccn.2003.08.002.

Abstract

Background: Lipoprotein lipase (LPL) mass is present in pre-heparin serum, although its activity is rarely detected. To clarify the dynamics of pre-heparin LPL mass during pregnancy, we studied the relationship between pre-heparin LPL mass and lipids in normal pregnant women.

Methods: Pre-heparin LPL mass and serum lipid levels were measured in 99 pregnant women during all three trimesters.

Results: When compared with the first and second trimesters, a significant decrease in pre-heparin LPL mass was observed in the third trimester. Plasma triglycerides were negatively correlated with pre-heparin LPL mass (r=-0.30; p<0.05). In contrast, LDL-C, HDL-C and total cholesterol did not exhibit a statistically significant correlation.

Conclusion: The decrease in pre-heparin LPL mass is manifested only during the third trimester.

MeSH terms

  • Analysis of Variance
  • Carrier Proteins / blood
  • Cholesterol / blood
  • Cholesterol Ester Transfer Proteins
  • Cholesterol, HDL / blood
  • Cholesterol, LDL / blood
  • Enzyme-Linked Immunosorbent Assay
  • Female
  • Glycoproteins / blood
  • Humans
  • Lactation / blood
  • Lipoprotein Lipase / blood*
  • Postpartum Period / blood*
  • Pregnancy
  • Pregnancy Trimesters / blood*
  • Triglycerides / blood

Substances

  • CETP protein, human
  • Carrier Proteins
  • Cholesterol Ester Transfer Proteins
  • Cholesterol, HDL
  • Cholesterol, LDL
  • Glycoproteins
  • Triglycerides
  • Cholesterol
  • Lipoprotein Lipase