Indium-catalyzed addition of active methylene compounds to 1-alkynes

Masaharu Nakamura; Kohei Endo; Eiichi Nakamura

doi:10.1021/ja038006m

Indium-catalyzed addition of active methylene compounds to 1-alkynes

J Am Chem Soc. 2003 Oct 29;125(43):13002-3. doi: 10.1021/ja038006m.

Authors

Masaharu Nakamura¹, Kohei Endo, Eiichi Nakamura

Affiliation

¹ Department of Chemistry, The University of Tokyo, Hongo, Bunkyo-ku, Tokyo 113-0033, Japan. masaharu@chem.s.u-tokyo.ac.jp

PMID: 14570454
DOI: 10.1021/ja038006m

Abstract

An active methylene compound adds to a 1-alkyne in high to quantitative yield upon heating in the presence of 0.05-5 mol % of In(OTf)3 to give an alpha-alkenylated carbonyl compound.