Intraflagellar transport

Annu Rev Cell Dev Biol. 2003;19:423-43. doi: 10.1146/annurev.cellbio.19.111401.091318.

Abstract

It has been a decade since a novel form of microtubule (MT)-based motility, i.e., intraflagellar transport (IFT), was discovered in Chlamydomonas flagella. Subsequent research has supported the hypothesis that IFT is required for the assembly and maintenance of all cilia and flagella and that its underlying mechanism involves the transport of nonmembrane-bound macromolecular protein complexes (IFT particles) along axonemal MTs beneath the ciliary membrane. IFT requires the action of the anterograde kinesin-II motors and the retrograde IFT-dynein motors to transport IFT particles in opposite directions along the MT polymer lattice from the basal body to the tip of the axoneme and back again. A rich diversity of biological processes has been shown to depend upon IFT, including flagellar length control, cell swimming, mating and feeding, photoreception, animal development, sensory perception, chemosensory behavior, and lifespan control. These processes reflect the varied roles of cilia and flagella in motility and sensory signaling.

Publication types

  • Research Support, U.S. Gov't, P.H.S.
  • Review

MeSH terms

  • Animals
  • Cell Movement / physiology*
  • Cilia / physiology
  • Dyneins / metabolism
  • Flagella / physiology*
  • Humans
  • Kinesin / metabolism
  • Macromolecular Substances
  • Microtubules / physiology
  • Molecular Motor Proteins / physiology*
  • Protein Transport / physiology

Substances

  • Macromolecular Substances
  • Molecular Motor Proteins
  • Dyneins
  • Kinesin