Meta and pooled analysis of European coeliac disease data

Eur J Hum Genet. 2003 Nov;11(11):828-34. doi: 10.1038/sj.ejhg.5201051.


Four full genome scans have been carried out by the partners of the European cluster on coeliac disease as well as follow-up studies of candidate regions. No region outside HLA showed significant linkage to the disease in any single study. We first applied a meta-analysis based on a modification of Genome Screen Meta-Analysis to take into account the different linkage statistics, the arbitrariness of bin cutoff points, as well as the sample size of each study. We then performed a pooled linkage analysis of all families and raw genotypes. Besides the HLA region, already known to harbour a risk factor for coeliac disease, both approaches leave very little doubt on the presence of a genetic risk factor in the 5q31-33 region. This region was suggested by several individual studies, but did not reach statistical values high enough to be conclusive when data sets were analysed separately.

Publication types

  • Research Support, Non-U.S. Gov't

MeSH terms

  • Celiac Disease / ethnology
  • Celiac Disease / genetics*
  • Chromosome Mapping
  • Computer Simulation
  • Europe
  • Genetic Linkage*
  • Genetic Markers
  • Genetic Predisposition to Disease
  • Genome, Human
  • HLA Antigens / genetics
  • Humans
  • Lod Score
  • Meta-Analysis as Topic


  • Genetic Markers
  • HLA Antigens