Gender differences in stability of the instantaneous patterns of body surface potentials during ventricular repolarisation

Med Biol Eng Comput. 2003 Sep;41(5):536-42. doi: 10.1007/BF02345315.


Women have a higher risk of developing torsade de pointes under OT-prolonging conditions. The electrophysiological differences between the sexes that could account for this are largely unknown. The objective of the work was to evaluate gender differences in repolarisation potentials using a method that is independent of the specific electrical properties of the thorax. 1410 normal recordings from the Glasgow 12-lead ECG database and 52 normal ECG maps obtained separately in Milan were analysed. The average difference between 1 and the correlation coefficient of the instantaneous pattern at the peak of T with that at every other instant is called the early repolarisation deviation index (ERDI) for J-T peak and the late repolarisation deviation index (LRDI) for T peak-T end. In standard ECG recordings, the ERDI was 0.42 +/- 0.22 in females compared with 0.19 +/- 0.16 in males (p < 10(-6)). The LRDI was higher in males under the age of 50. In body surface maps, the ERDI was 0.32 +/- 0.21 in females against 0.16 +/- 0.17 in males (p < 0.01), and the LRDI was non-significantly higher in males. The pattern of instantaneous body surface potentials showed gender differences during repolarisation with a method that is independent of the electrical properties of the thorax.

Publication types

  • Research Support, Non-U.S. Gov't

MeSH terms

  • Adolescent
  • Adult
  • Body Surface Potential Mapping / methods*
  • Female
  • Humans
  • Male
  • Middle Aged
  • Reference Values
  • Sex Characteristics*
  • Signal Processing, Computer-Assisted
  • Ventricular Function