Crosstalk between cAMP and Ca2+ signaling in non-excitable cells

Cell Calcium. 2003 Dec;34(6):431-44. doi: 10.1016/s0143-4160(03)00150-7.


An impressive array of cytosolic calcium ([Ca2+](i)) signals exert control over a broad range of physiological processes. The specificity and fidelity of these [Ca2+](i) signals is encoded by the frequency, amplitude, and sub-cellular localization of the response. It is believed that the distinct characteristics of [Ca2+](i) signals underlies the differential activation of effectors and ultimately cellular events. This "shaping" of [Ca2+](i) signals can be achieved by the influence of additional signaling pathways modulating the molecular machinery responsible for generating [Ca2+](i) signals. There is a particularly rich source of potential sites of crosstalk between the cAMP and the [Ca2+](i) signaling pathways. This review will focus on the predominant molecular loci at which these classical signaling systems interact to impact the spatio-temporal pattern of [Ca2+](i) signaling in non-excitable cells.

Publication types

  • Research Support, U.S. Gov't, P.H.S.
  • Review

MeSH terms

  • Animals
  • Calcium / metabolism*
  • Calcium Channels / metabolism
  • Calcium Signaling*
  • Cyclic AMP / metabolism*
  • Cytosol / metabolism
  • Humans
  • Inositol 1,4,5-Trisphosphate / metabolism
  • Models, Biological
  • Pancreas / cytology
  • Pancreas / metabolism*
  • Receptors, Cell Surface / metabolism
  • Ryanodine Receptor Calcium Release Channel / metabolism
  • Second Messenger Systems*


  • Calcium Channels
  • Receptors, Cell Surface
  • Ryanodine Receptor Calcium Release Channel
  • Inositol 1,4,5-Trisphosphate
  • Cyclic AMP
  • Calcium