Stu2p and XMAP215: turncoat microtubule-associated proteins?

Trends Cell Biol. 2003 Nov;13(11):547-50. doi: 10.1016/j.tcb.2003.09.006.


The dynamics of microtubule-based (MT) cytoskeletons are controlled by a variety of accessory proteins: microtubule-associated proteins (MAPs), which usually stabilize MTs, and microtubule-destabilizers. Two related MAPs, XMAP215 and Stu2p, are known to stabilize MTs. However, recent studies report that these proteins have a MT-destabilizing function as well. Here we discuss the implications of these reports.

MeSH terms

  • Animals
  • Microtubule-Associated Proteins / genetics
  • Microtubule-Associated Proteins / physiology*
  • Microtubules / genetics
  • Microtubules / physiology*
  • Saccharomyces cerevisiae
  • Saccharomyces cerevisiae Proteins / genetics
  • Saccharomyces cerevisiae Proteins / physiology*
  • Xenopus Proteins / physiology


  • CKAP5 protein, Xenopus
  • Microtubule-Associated Proteins
  • STU2 protein, S cerevisiae
  • Saccharomyces cerevisiae Proteins
  • Xenopus Proteins