Treatment of neurosyphilis with ceftriaxone

Sex Transm Infect. 2003 Oct;79(5):415-6. doi: 10.1136/sti.79.5.415.


The first choice treatment for late syphilis is penicillin. Other than doxycycline, which penetrates the CNS, there are few alternatives for the treatment of neurosyphilis. We report a case of successful treatment of symptomatic neurosyphilis with parenteral ceftriaxone.

Publication types

  • Case Reports

MeSH terms

  • Antitreponemal Agents / administration & dosage*
  • Ceftriaxone / administration & dosage*
  • Humans
  • Male
  • Middle Aged
  • Neurosyphilis / drug therapy*
  • Treatment Outcome


  • Antitreponemal Agents
  • Ceftriaxone