Cyclosporine interactions with miconazole and other azole-antimycotics: a case report and review of the literature

J Heart Lung Transplant. Nov-Dec 1992;11(6):1127-32.

Abstract

Several antimicrobial drugs have been shown to pharmacokinetically interact with cyclosporine. On two separate occasions, we observed increases in cyclosporine plasma concentrations during concomitant miconazole therapy in a heart transplant patient with an infection secondary to Pseudallescheria boydii. To our knowledge, no interaction between cyclosporine and miconazole has previously been reported. In addition, drug interactions were observed between cyclosporine and ketoconazole and possibly between cyclosporine and SCH 39304, an investigational azole-antifungal agent. No interaction was noted between cyclosporine and fluconazole. In general, clinicians should anticipate drug interactions between cyclosporine and azole-antimycotic agents.

Publication types

  • Case Reports
  • Review

MeSH terms

  • Antifungal Agents / pharmacology*
  • Antifungal Agents / therapeutic use
  • Cyclosporine / pharmacokinetics
  • Cyclosporine / pharmacology*
  • Drug Interactions
  • Heart Transplantation*
  • Humans
  • Immunosuppression
  • Ketoconazole / pharmacology
  • Lung Diseases, Fungal / drug therapy
  • Lung Diseases, Fungal / microbiology
  • Male
  • Miconazole / pharmacology*
  • Miconazole / therapeutic use
  • Middle Aged
  • Pseudallescheria
  • Triazoles / pharmacology

Substances

  • Antifungal Agents
  • Triazoles
  • Sch 39304
  • Miconazole
  • Cyclosporine
  • Ketoconazole