Pathogenesis of and immunity to a new influenza A (H5N1) virus isolated from duck meat

Avian Dis. 2003;47(3 Suppl):1135-40. doi: 10.1637/0005-2086-47.s3.1135.


The outbreak of avian influenza H5N1 in Hong Kong in 1997 raised concerns about the potential for the H5 subtype to cause a human pandemic. In 2001 a new H5N1 virus, A/Duck Meat/Anyang/AVL-1/2001 (A/Dkmt), was isolated from imported duck meat in Korea. The pathogenesis of this virus was investigated in mice. A/Dkmt virus had low infectivity but was lethal for mice at high doses, and at lethal doses, the virus replicated in the brains of infected mice. A/Dkmt virus cross-reacted poorly with ferret antisera raised against human H5N1 viruses, but prior infection with A/Dkmt virus protected mice from death after secondary infection with human H5N1 virus.

MeSH terms

  • Animals
  • Body Weight
  • Cross Infection / prevention & control
  • Disease Outbreaks / veterinary
  • Ducks / virology*
  • Hong Kong / epidemiology
  • Humans
  • Influenza A Virus, H5N1 Subtype*
  • Influenza A virus / immunology
  • Influenza A virus / isolation & purification
  • Influenza A virus / pathogenicity*
  • Influenza in Birds / physiopathology*
  • Meat / virology*
  • Mice
  • Mice, Inbred BALB C
  • Time Factors
  • Virus Replication / physiology*
  • Zoonoses / epidemiology