Head-to-tail oxime cyclization of oligodeoxynucleotides for the efficient synthesis of circular DNA analogues

J Org Chem. 2003 Oct 31;68(22):8708-10. doi: 10.1021/jo035064h.

Abstract

A convenient strategy for the synthesis of the analogue of cyclic oligodeoxyribonucleotides is presented. The cyclization of the oligonucleotide was accomplished through intramolecular oxime bond formation between a 5'-oxyamine moiety and a 3'-aldehydic group.

Publication types

  • Research Support, Non-U.S. Gov't

MeSH terms

  • Aldehydes / chemistry
  • Cyclization
  • DNA, Circular / chemical synthesis*
  • Models, Chemical
  • Oligodeoxyribonucleotides / chemical synthesis*
  • Oximes / chemical synthesis*
  • Sequence Analysis

Substances

  • Aldehydes
  • DNA, Circular
  • Oligodeoxyribonucleotides
  • Oximes