At the Crossroads: AMP-activated Kinase and the LKB1 Tumor Suppressor Link Cell Proliferation to Metabolic Regulation

J Biol. 2003;2(4):26. doi: 10.1186/1475-4924-2-26. Epub 2003 Oct 22.

Abstract

The tumor suppressor kinase LKB1 has been identified as a physiologic activator of the key metabolic regulator 5'-AMP-activated protein kinase, establishing a possible molecular link between the regulation of metabolism and cell proliferation.

Publication types

  • Review

MeSH terms

  • AMP-Activated Protein Kinases
  • Animals
  • Cell Growth Processes / physiology*
  • Cell Proliferation*
  • Genes, Tumor Suppressor / physiology*
  • Humans
  • Multienzyme Complexes / physiology*
  • Protein-Serine-Threonine Kinases / physiology*

Substances

  • Multienzyme Complexes
  • STK11 protein, human
  • Protein-Serine-Threonine Kinases
  • AMP-Activated Protein Kinases