A whole genome association study in Icelandic multiple sclerosis patients with 4804 markers

J Neuroimmunol. 2003 Oct;143(1-2):88-92. doi: 10.1016/j.jneuroim.2003.08.018.


Multiple sclerosis (MS) is a demyelinating disorder of the central nervous system (CNS) with a complex genetic background. Here we use a genome-wide association strategy with 4804 microsatellite markers successfully typed in separately pooled DNA from 200 patients and 200 controls. A total of 91 markers showed evidence of association. When compared to our in-house physical map of the genome, six 2-Mb regions containing at least two of these markers were detected. Of those, three regions have one or more markers among the 20 most strongly associated: chromosomes 3q25, 6p21.3 (the MHC region) and 19q13.

Publication types

  • Research Support, Non-U.S. Gov't

MeSH terms

  • Case-Control Studies
  • Female
  • Genetic Predisposition to Disease
  • Genetic Testing / methods*
  • Genetic Testing / statistics & numerical data
  • Genome, Human*
  • Genotype
  • Humans
  • Iceland / epidemiology
  • International Cooperation
  • Male
  • Microsatellite Repeats*
  • Middle Aged
  • Multiple Sclerosis / epidemiology
  • Multiple Sclerosis / genetics*