Two genome-wide linkage disequilibrium screens in Scandinavian multiple sclerosis patients

J Neuroimmunol. 2003 Oct;143(1-2):101-6. doi: 10.1016/j.jneuroim.2003.08.021.


We report the first two genome-wide screens for linkage disequilibrium between putative multiple sclerosis (MS) susceptibility genes and genetic markers performed in the genetically homogenous Scandinavian population, using 6000 microsatellite markers and DNA pools of approximately 200 MS cases and 200 controls in each screen. Usable data were achieved from the same 3331 markers in both screens. Nine markers from eight genomic regions (1p33, 3q13, 6p21, 6q14, 7p22, 9p21, 9q21 and Xq22) were identified as potentially associated with MS in both screens.

Publication types

  • Multicenter Study
  • Research Support, Non-U.S. Gov't

MeSH terms

  • Alleles
  • Chromosomes, Human, Pair 6 / genetics
  • Female
  • Genetic Predisposition to Disease
  • Genetic Testing / methods*
  • Genetic Testing / statistics & numerical data
  • Genome, Human*
  • Genotype
  • Histocompatibility Testing
  • Humans
  • Linkage Disequilibrium / genetics*
  • Male
  • Microsatellite Repeats
  • Multiple Sclerosis / epidemiology
  • Multiple Sclerosis / genetics*
  • Scandinavian and Nordic Countries / epidemiology