Alternative splicing and evolution

Bioessays. 2003 Nov;25(11):1031-4. doi: 10.1002/bies.10371.


Alternative splicing is a critical post-transcriptional event leading to an increase in the transcriptome diversity. Recent bioinformatics studies revealed a high frequency of alternative splicing. Although the extent of AS conservation among mammals is still being discussed, it has been argued that major forms of alternatively spliced transcripts are much better conserved than minor forms. It suggests that alternative splicing plays a major role in genome evolution allowing new exons to evolve with less constraint.

Publication types

  • Review

MeSH terms

  • Alternative Splicing*
  • Animals
  • Antigens, Surface / genetics
  • Antigens, Surface / metabolism
  • Computational Biology
  • Evolution, Molecular*
  • Exons
  • Humans
  • Introns
  • Milk Proteins / genetics
  • Milk Proteins / metabolism


  • Antigens, Surface
  • MFGE8 protein, human
  • Milk Proteins