Interaction Between Bacteriophage Lambda and Its Escherichia Coli Host

Curr Opin Genet Dev. 1992 Oct;2(5):727-38. doi: 10.1016/s0959-437x(05)80133-9.


Bacteriophage lambda relies to a large extent on processes requiring interactions between viral- and host-encoded proteins for its lytic growth, establishment of lysogeny, and release from the prophage state. Both biochemical and genetic studies of these interactions have yielded new information about important host and lambda functions. In particular, mutations in Escherichia coli that compromise lambda DNA replication, genome packaging, transcription elongation, and site-specific recombination have led to the identification of bacterial genes whose products are chaperones, transcription factors, or DNA-binding proteins.

Publication types

  • Review

MeSH terms

  • Bacterial Proteins / genetics
  • Bacterial Proteins / metabolism
  • Bacteriophage lambda / genetics
  • Bacteriophage lambda / physiology*
  • DNA-Binding Proteins / genetics
  • DNA-Binding Proteins / metabolism
  • Escherichia coli / genetics
  • Escherichia coli / physiology*
  • Gene Expression Regulation, Bacterial
  • Gene Expression Regulation, Viral
  • Lysogeny*
  • RNA-Binding Proteins / genetics
  • RNA-Binding Proteins / metabolism
  • Viral Proteins / genetics
  • Viral Proteins / metabolism
  • Virus Activation
  • Virus Integration
  • Virus Replication*


  • Bacterial Proteins
  • DNA-Binding Proteins
  • RNA-Binding Proteins
  • Viral Proteins
  • rexB protein, Bacteriophage lambda