HIS & HERS, magic magnesium and the ballet of protein synthesis

K Mark Parnell; Scott A Strobel

doi:10.1016/j.cbpa.2003.08.003

HIS & HERS, magic magnesium and the ballet of protein synthesis

Curr Opin Chem Biol. 2003 Oct;7(5):528-33. doi: 10.1016/j.cbpa.2003.08.003.

Authors

K Mark Parnell¹, Scott A Strobel

Affiliation

¹ Department of Molecular Biophysics and Biochemistry, Yale University, 260 Whitney Ave, New Haven, CT 06520-8114, USA.

PMID: 14580554
DOI: 10.1016/j.cbpa.2003.08.003

Abstract

The peptidyl transferase center of the ribosome is literally the mother of all protein enzymes, yet it was only recently that the content of its active site was found to be RNA and not protein. This review focuses on how this RNA enzyme orients its substrates and promotes the chemical reaction that is center stage in protein synthesis.

Publication types

Research Support, Non-U.S. Gov't
Review

MeSH terms

Catalysis
Enzyme Stability
Magnesium / metabolism*
Molecular Structure
Peptidyl Transferases / metabolism*
Protein Biosynthesis*
RNA, Ribosomal / metabolism*
Ribosomes / metabolism
Substrate Specificity

Substances

RNA, Ribosomal
Peptidyl Transferases
Magnesium